NORMAN, Okla. — Sam Bradford and Oklahoma are on their way up in the national championship race, and Texas Tech sure came down with a mighty fall.

Bradford threw for 304 yards and four touchdowns, and DeMarco Murray and Chris Brown combined to run for five more scores as the fifth-ranked Sooners brought an unceremonious end to No. 2 Texas Tech's run toward perfection in a 65-21 blowout Saturday night.

The question now is this: Did the Sooners (10-1, 6-1 Big 12) do enough to make up for that loss to Texas?

Graham Harrell, who came into Norman as the Heisman Trophy favorite, was 33-for-55 for 361 yards and three touchdowns.

The Red Raiders (10-1, 6-1) fell into a three-way tie atop the Big 12 South with Texas and Oklahoma, with only one week left in the regular season. If the three finished tied, the BCS standings would determine which team plays No. 12 Missouri in the Big 12 championship game in Kansas City, Mo., on Dec. 6.

No. 7 Penn State 49, No. 17 Michigan State 18

In State College, Pa., Daryll Clark threw for career-highs of 341 yards and four touchdowns and a stingy Penn State defense held Javon Ringer to a season-low 42 yards.

With Paterno coaching again from the press box because of a sore hip, Penn State (11-1, 7-1) secured a share of the conference title and the school's first trip to Pasadena since 1995.

No. 3 Florida 70, Citadel 19

In Gainesville, Fla., Tim Tebow threw for 201 yards and three touchdowns and Chris Rainey ran for 142 yards and a score.

Florida (10-1) scored touchdowns on its first seven possessions and racked up 512 yards in the first half alone.

No. 9 Boise State 41, Nevada 34

In Reno, Nev., Kellen Moore threw for 414 yards and three touchdowns and Boise State kept the nation's best rushing offense in check to remain undefeated.

Moore threw for 319 yards by halftime, when the Broncos led 24-3.

Colin Kaepernick passed for 241 yards and a touchdown and ran for 70 yards for Nevada (6-5, 4-3 WAC).

No. 10 Ohio St. 42, Michigan 7

In Columbus, Ohio, the Buckeyes won their fifth straight over Michigan for the first time and ending a dreadful first season for Wolverines coach Rich Rodriguez.

The Buckeyes (10-2, 7-1) used five big plays to win by the biggest margin in the rivalry since Woody Hayes in a 50-14 rout of Michigan in 1968.

Freshman phenom Terrelle Pryor threw two TD passes, Brian Hartline caught two scoring passes and Dan Herron ran for two more touchdowns to give the Buckeyes a share of their fourth straight Big Ten title.

Mississippi 31, No. 18 LSU 13

In Baton Rouge, La., Jevan Snead threw two touchdown passes, and Markeith Summers ran for a 13-yard score out of the "Wild Rebel" formation to give the Rebels their fourth straight win.

Ole Miss (7-4, 4-3 Southeastern Conference) snapped a six-game losing streak against LSU (7-4, 3-4) with its first win in the long rivalry since 2001.

Snead was 16 of 25 for 274 yards. His scoring passes went for 34 and 25 yards, both to Mike Wallace.

No. 19 Cincinnati 28, No. 20 Pittsburgh 14

In Cincinnati, Tony Pike threw three touchdown passes despite a broken arm and led the Bearcats to the threshold of their first Big East championship with their first win in eight games against the Panthers (7-3, 3-2).

No. 21 Oregon State 19, Arizona 17

In Tucson, Ariz., Justin Kahut hit a 24-yard field goal as time expired to get the Beavers one victory away from their first Rose Bowl trip since 1965.

The Beavers (8-3, 7-1 Pac-10) can clinch a trip to Pasadena, Calif., with a victory over No. 24 Oregon in the Civil War on Nov. 29.

Florida State 37, No. 22 Maryland 3

In College Park, Md., Florida State kept alive its hopes of advancing to the Atlantic Coast Conference championship game and buried Maryland's title hopes under a barrage of sacks and takeaways.

Everette Brown had 31/2 sacks and forced a fumble, part of an overwhelming performance by the Seminoles' defense.

Florida State (8-3, 5-3) turned two turnovers into touchdowns in taking a 21-0 halftime lead. That was enough to ensure Maryland (7-4, 4-3) its first home loss of the season.

N.C. State 41, No. 25 North Carolina 10

In Chapel Hill, N.C., Russell Wilson threw for two touchdowns and had a key run in the third quarter to set up another score, and N.C. State earned the program's first season sweep of the state's four other major college teams in more than two decades.

Jamelle Eugene ran for two touchdowns and Andre Brown ran for another for N.C. State (5-6, 3-4 Atlantic Coast Conference), which kept its bowl hopes alive.